Natural anti-aging advice and
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Dr. Kevin McLaughlin,
Anti-Aging Expert

Why Price Doesn’t Matter When It Comes to Anti-Wrinkle Creams

Why Price Doesn’t Matter When It Comes to Anti-Wrinkle CreamsWhen it comes to anti-wrinkle creams, it’s common sense that not every skin cream is created equally. Regardless of price, brand, or “claims to fame,” not all anti-wrinkle creams are as effective as they say they are. But that’s not to say that all over-the-counter anti-wrinkle creams are ineffective—what it comes down to is the key ingredients.

According to a study by Consumer Reports magazine, there is no direct correlation between “high quality” expensive skin creams and the diminishment of wrinkles. Covering a range of price points, the study tested nine of the most popular over-the-counter anti-wrinkle creams. Researchers had nearly 300 female participants between the ages of 30 and 70 test these creams over a 12-week period. At the end of these 12 weeks, researchers examined photos of the women for the length and depth of their wrinkles.

According to researchers, the top reduction in the depth of wrinkles among the creams tested was 10%. However, new research on the key ingredients of some of the most clinically advanced anti-wrinkle creams suggests that what’s in a cream is more telling of its effectiveness than its brand or price. In particular, Argireline, Leuphasyl, Matrixyl-6, and Alpine rose plant stem cells are the front-runners when it comes to anti-wrinkle cream ingredients, the latter two being quite new to the market.

Argireline and Leuphasyl

Argireline has been proven to be effective in the reduction of under-eye wrinkles. In a study published in the International Journal of Cosmetic Science, Argireline (Acetyl-hexapeptide-8) was proven to diminish the depth of wrinkles around the eyes by 30% in just 30 days. Plus, when added to Leuphasyl, the effectiveness of Argireline can reach a 47% reduction in the depth of wrinkles after just 28 days of continued use.


New to the market, Matrixyl-6 is a powerful peptide and anti-wrinkle fighter. In a study involving 25 female volunteers (aged 42–70 years), Matrixyl-6 was found to improve the smoothness of skin on the forehead and around the eyes. According to the study’s findings, Matrixyl-6 had a 12.6% lifting effect and a 15% reduction in wrinkle depth. But when it came to the peptide’s effects on forehead wrinkles, Matrixyl-6 lifted the skin on the forehead by up to 77%, reducing maximum wrinkle depth by up to 62%.

Alpine Rose Extract

Researchers have just discovered that Alpine rose extract is effective against wrinkles as well. In just two months, volunteers of one study saw their wrinkles reduced by 33% and dark circles improved by 19%. Because the Alpine rose has an amazing extended lifespan of 100 years and is able to adapt to extreme climate changes, including ultraviolet (UV) levels, the extract from this flower works to preserve human skin cells while battling the effects of aging. In an anti-wrinkle cream, alpine rose extract can be a potent wrinkle fighter.

So as research is proving, not all anti-wrinkle creams are effective; but if it has the right ingredients—like Argireline, Leuphasyl, Matrixyl-6, and Alpine rose extract, for example—the potency of that particular anti-wrinkle cream could be as effective as many surgical treatments, minus the side effects.

“Alpine Rose Active: Combats aging by protecting skin proteins,” Mibelle AG Biochemistry web site;
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“Argireline: An Anti-Wrinkle GMP Hexapeptide,” Renew Cosmetics Ltd. web site;, last accessed June 7, 2013.
Blanes-Mira, C., et al., “A synthetic hexapeptide (Argireline) with antiwrinkle activity,” International Journal of Cosmetic Science 2002; 24: 303–310.
Goldfaden, G., et al., “Activate Self-Renewing Skin Stem Cells,” Life Extension web site;, last accessed June 7, 2013.
Leuphasyl,” web site;, last accessed June 7, 2013.
“MATRIXYL synthe’6,” SkinAgain web site;
oztone/matrixyl-synthe6_promotional_sheet_usa.pdf, last accessed June 7, 2013.
“User Reviews & Ratings—Botox Cosmetic IM,” WebMD web site;
IM.aspx?drugid=63955&drugname=Botox+Cosmetic+IM, last accessed June 7, 2013.

The information contained herein is for information purposes only and is not to be construed as a diagnosis, treatment, preventive, or cure for any disease, disorder, or abnormal physical state, nor should it be considered a substitute for medical care from your doctor. On any matter relating to your health or well-being—and prior to undertaking any health-related activity—consult an appropriate health professional. The opinions herein are exactly that, they are the opinions of the author., a division of Agein Corporation and its employees are not responsible for medically unsupervised activities that could be harmful to your health.

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